|
MOHS
Jun 30, 2013 11:05:23 GMT -5
Post by sheltie on Jun 30, 2013 11:05:23 GMT -5
It's already hot outside this morning and I'm sitting around inside where it is cool waiting for sports to be on the TV. In the meantime, my mind has been wandering and I'm left with this question. Is there any connection between the MOHS scale and MOHS surgery? Unfortunately, I'm more intimately familiar with the latter than the former, although I certainly know the scale.
|
|
|
MOHS
Jun 30, 2013 17:37:52 GMT -5
Post by deb193redux on Jun 30, 2013 17:37:52 GMT -5
well the 1st names are similar too, but substance aside, a century and an ocean separate them
one was created in 1812 by the German geologist and mineralogist Friedrich Mohs, born in Gernrode, Germany, studied chemistry, mathematics and physics at the University of Halle and also studied at the Mining Academy in Freiberg, Saxony. -- the other was developed in 1938 by a general surgeon, Dr. Frederic E. Mohs,born in Burlington, Wisconsin. His father died when he was 3 months old, and the family moved to Madison, where his mother ran a boarding house.
|
|
|
MOHS
Jun 30, 2013 17:50:05 GMT -5
Post by sheltie on Jun 30, 2013 17:50:05 GMT -5
Thank God for Google!
|
|
|
MOHS
Jun 30, 2013 18:29:09 GMT -5
Post by deb193redux on Jun 30, 2013 18:29:09 GMT -5
yes, I am not quite nerdy enough to have known that off hand ... but the thanks go to Wikipedia
|
|
|
MOHS
Jun 30, 2013 19:56:19 GMT -5
Post by vegasjames on Jun 30, 2013 19:56:19 GMT -5
No There is no relation. Mohs surgery is named after the doctor who came up with the procedure, Frederic Moh. The procedure is done for skin cancers, and is kind of like following a vein of ore. In this case though areas of skin are removed and examined in each step to map out where to continue to remove tissue.
Personally I think there are some severe limitations with this surgery. For one, cutting through potentially cancerous tissues increases the risk of metastases. Conventional surgery would take the suspected caner by cutting a larger border around the suspect spot. Safer, but more destructive so there is a trade off. The second problem is that as with all surgeries for cancer the surgery does not address the cause of the cancer, which is almost always viral infections. In the case of skin cancer, skin cancers have been linked to HPV viruses. If the virus remains it can cause a recurrence of the cancer just like it caused the original cancer. This is one of the reasons cancer tends to come back within a few years after chemotherapy, radiation therapy or surgery. These generally do not address cancer microbes that have been linked to most cancers including the so-called "hereditary" cancers. The only cancer that has ever been shown to even have the remote possibility of being hereditary is infantile retinoblastoma. The oncogenes of other cancers that have been claimed to be hereditary, such as breast cancer, have all been found to be viral in origin.
This is also why the only chemotherapy drugs that have ever been shown to have any reasonable success rates are the drugs Vincristine and Vinblastine derived from the plant Madagascar periwinkle. These drugs have around an 80% success rate for leukemias and lymphomas because both of these forms of cancer are caused from viruses and Vincristine and Vinblastine are highly anti-viral drugs.
|
|
|
MOHS
Jun 30, 2013 21:39:12 GMT -5
Post by Peruano on Jun 30, 2013 21:39:12 GMT -5
thanks for the detail. Tom
|
|
|
MOHS
Jun 30, 2013 22:34:43 GMT -5
Post by helens on Jun 30, 2013 22:34:43 GMT -5
The second problem is that as with all surgeries for cancer the surgery does not address the cause of the cancer, which is almost always viral infections. In the case of skin cancer, skin cancers have been linked to HPV viruses. If the virus remains it can cause a recurrence of the cancer just like it caused the original cancer. I had read in the past that cancer can be caused by virus, but I never pursued it...just looked it up, and whoa... this is stunning information: en.wikipedia.org/wiki/OncovirusI had not realized so many cancers were associated with virus... and virus are transmittable person to person. That's scary. Are you a doctor? Rather than wait for an answer, you seem familiar with skin cancer particularly, I hope you can answer a question for me. 1. Would you buy a piece of equipment to help you diagnose skin cancer if it proved to be more effective than the usual biopsy and visual ID? If so, would you consider this one? Why and why not? melasciences.com/melafindThe machine is here: www.melafind.com/patients/about-melafind#about-melafindWhat about this system? www.verisante.com/www.verisante.com/products/aura/This is actually a stock related question... and I'm trying to figure out market potential. They may both work (according to Verisante, theirs works better), but would doctors BUY them is the question. If you aren't in the skin cancer field, no biggie, thought I'd ask. If you are, and you would, you might want to look into them also.
|
|
|
MOHS
Jun 30, 2013 23:35:22 GMT -5
Post by vegasjames on Jun 30, 2013 23:35:22 GMT -5
The second problem is that as with all surgeries for cancer the surgery does not address the cause of the cancer, which is almost always viral infections. In the case of skin cancer, skin cancers have been linked to HPV viruses. If the virus remains it can cause a recurrence of the cancer just like it caused the original cancer. I had read in the past that cancer can be caused by virus, but I never pursued it...just looked it up, and whoa... this is stunning information: en.wikipedia.org/wiki/OncovirusI had not realized so many cancers were associated with virus... and virus are transmittable person to person. That's scary. Are you a doctor? Rather than wait for an answer, you seem familiar with skin cancer particularly, I hope you can answer a question for me. 1. Would you buy a piece of equipment to help you diagnose skin cancer if it proved to be more effective than the usual biopsy and visual ID? If so, would you consider this one? Why and why not? melasciences.com/melafindThe machine is here: www.melafind.com/patients/about-melafind#about-melafindWhat about this system? www.verisante.com/www.verisante.com/products/aura/This is actually a stock related question... and I'm trying to figure out market potential. They may both work (according to Verisante, theirs works better), but would doctors BUY them is the question. If you aren't in the skin cancer field, no biggie, thought I'd ask. If you are, and you would, you might want to look into them also. The list of viral induced cancers is a lot longer than what was posted on Wiki. Cancers linked in stuides to viruses include leukemias, lymphomas, Kaposi's sarcoma, skin, breast, prostate, penile, naso-pharyngeal, esophageal, ano-genital, vulvar, ovarian, uterine, cervical, liver, kidney, salivary, brain (including glioma and medulloblastoma), osteosarcoma, bladder, leiosarcomas, gastric, colon and lung cancers. No, I am not a doctor, but I have been in medicine for 32 years and have been researching cancer for nearly as long. The first machine is way too limited in both detection and areas that can be used. This can lead to unnecessary biopsies. The second machine looks much better. Raman spectroscopy could detect specific markers for malignant cells, which would reduce the use of unnecessary biopsies. Still this machine is somewhat limited. There are ways in which cancer cells could be positively identified without the need for biopsies at all. One of the projects I have been working on is for this reason. Unfortunately I don't have the funding or access to the equipment needed to finish this up yet, but have been working towards both.
|
|
|
MOHS
Jul 1, 2013 0:17:29 GMT -5
Post by helens on Jul 1, 2013 0:17:29 GMT -5
Interesting, thanks for the quick opinion, that's what I needed to know... explore the concepts with a Venture Capital firm?
|
|
|
MOHS
Jul 1, 2013 8:17:46 GMT -5
Post by sheltie on Jul 1, 2013 8:17:46 GMT -5
Very interesting. I'm facing my third, and possibly fourth, MOHS surgery. I'm waiting for two biopsy results to come back and am pretty sure one will be basal cell and the other possibly melanoma (in which case it won't be a MOHS surgery, but more extensive). I played gold for almost 65 years of my life, never used sunscreen and have assumed all along that it would catch up with me. It did and none of my dermatologists have even suggested to me that my cancers were caused by anything other than exposure to the sun. Never a word about a virus. I'll have to bring that up when I go in probably this week.
Now I'm glad it was so hot and I was bored yesterday. At least I've learned something.
|
|
|
MOHS
Jul 1, 2013 15:56:08 GMT -5
Post by vegasjames on Jul 1, 2013 15:56:08 GMT -5
Very interesting. I'm facing my third, and possibly fourth, MOHS surgery. I'm waiting for two biopsy results to come back and am pretty sure one will be basal cell and the other possibly melanoma (in which case it won't be a MOHS surgery, but more extensive). I played gold for almost 65 years of my life, never used sunscreen and have assumed all along that it would catch up with me. It did and none of my dermatologists have even suggested to me that my cancers were caused by anything other than exposure to the sun. Never a word about a virus. I'll have to bring that up when I go in probably this week. Now I'm glad it was so hot and I was bored yesterday. At least I've learned something. Sunlight is not the cause of the cancer it is a co-factor. Sunlight activates the HPV virus in the skin that causes the skin cancer. This is why everyone that spends a lot of time in the sun does not develop skin cancer. I used to race triathlons and did cross country bicycling so I was in the sun literally all day long almost every day. I never used sunscreen, which actually contains various carcinogens. Still, I never had any problems with skin cancer or even skin damage. There is so much more to the issue such as nutrition, immune status, etc. It is the same with "hormonal" cancers. The hormones do not cause the cancer, they activate cancer viruses then can act as growth promoters in existing cancers.
|
|
Deleted
Deleted Member
Member since January 1970
Posts: 0
|
MOHS
Jul 1, 2013 16:29:02 GMT -5
Post by Deleted on Jul 1, 2013 16:29:02 GMT -5
I lost a dear friend to skin cancer. His first was in a place the sun never shines. His was melanoma.
His personal research into the scientific literature and discussions with his doctor's indicated 99% of melanoma's show up first in places the sun never shines. Think butt crack, the 'taint or betweenunder toes. Using this knowledge it stands to reason that, for melanoma, the sun may be protective from it's occurrence.
Tom was part of a successful clinical trial in which a vaccine was used to treat melanoma. When he had lumps removed the histology always indicated the nodule was 75% dead. Still it wasn't enough to kill the growth and eventually.... well... you know the rest.
|
|
|
MOHS
Jul 1, 2013 16:44:46 GMT -5
Post by vegasjames on Jul 1, 2013 16:44:46 GMT -5
Another point that should be brought up is that sunlight increases vitamin D levels, which is actually anti-cancer. So there is a lot of hype over sunlight causing skin cancer.
You are right about the melanomas. Consider how often people develop them on their backs even though they always wear shirts out in the sun. Again, the sun does not cause the cancer, the virus causes the cancer and there can be various triggers that activate cancer viruses such as sunlight, hormones, carcinogens, immune suppression, other viruses, etc.
|
|
|
MOHS
Jul 1, 2013 18:19:02 GMT -5
Post by sheltie on Jul 1, 2013 18:19:02 GMT -5
I'm getting depressed. All this worrying by me before I even get the results of my biopsies back. I did some research on melanomas and, if that is what I have, hope to have one of the earlier state types. Unfortunately, this particular growth (on my upper chest) was biopsied nine years ago and found to be a mole and has not been tested since then, although it has been checked twice a year since then. I started a new dermatologist this past week and when she received the files from my ex-doctor she discovered that the growth was triple the size of nine years ago. So she took a slice and now we wait. The worst part of anything is waiting. I feel like I'm back in the Army again almost 35 years after I retired! The way I look at it is that the three preceding males in my background (father, grand father, and great) all died before 65. So it that regard, I'm lucky. I'm almost 72, in relatively decent health other than those things that affect old pharts, all of which I attribute to having a very athletic and active life. But I guess even healthy people can evade a virus if that's the way it has to be.
|
|
|
MOHS
Jul 2, 2013 1:21:57 GMT -5
Post by vegasjames on Jul 2, 2013 1:21:57 GMT -5
Don't get depressed. There are things that can be done. For example, there are many antiviral compounds that are quite effective against cancers as well such as betulinic acid. And cancer cells can be selectively killed by several means. For example, skin cancers can be selectively treated with the application of food grade (35%) peroxide. The process is painful though as concentrated peroxide burns like you are being branded. Only hurts for about 20 minutes though.
|
|
|
MOHS
Jul 2, 2013 3:45:24 GMT -5
Post by helens on Jul 2, 2013 3:45:24 GMT -5
You are full of tantalizing factoids, James!!!
Peroxide kills skin cancer?! Wouldn't that be topical only? How would that get to the subcutaneous portions of the tumor?? Can you actually get ahead of tumor growth by continuously killing the visible part of it (with the peroxide), wouldn't it eventually grow inward so the peroxide would eventually become ineffective?
And I actually wondered about this... why wouldn't lasers work on skin cancer, the under skin types? They have multiple different lasers for melting fat under skin layers now, if it can melt fat, couldn't they be directed at melting tumors from within?
Great subject!
|
|
Deleted
Deleted Member
Member since January 1970
Posts: 0
|
MOHS
Jul 2, 2013 12:44:42 GMT -5
Post by Deleted on Jul 2, 2013 12:44:42 GMT -5
Another point that should be brought up is that sunlight increases vitamin D levels, which is actually anti-cancer. So there is a lot of hype over sunlight causing skin cancer. You are right about the melanomas. Consider how often people develop them on their backs even though they always wear shirts out in the sun. Again, the sun does not cause the cancer, the virus causes the cancer and there can be various triggers that activate cancer viruses such as sunlight, hormones, carcinogens, immune suppression, other viruses, etc. Thanks James! (or do you go by Jim?) This topic is dear to me for the personal connection I mentioned earlier. There was a study in Australia regarding skin cancer and sunscreen. Perhaps not coincidentally, sunscreen was invented in Australia. The incidence of skin cancer's of all kinds increased beginning the year after sunscreen was introduced to the public. It continued to increase until it found a new plateau. Further, that study referred (or vise versa) to another Aussie study in which they surveyed skin cancer patients in many various job descriptions. The highest rate of skin cancer was among office workers of all kinds. Lifeguarding is a real career there so there are great numbers of folks who spend 200++ days a year for 20++ years in the sun, and the study showed they have the lowest rate of skin cancer.
|
|
Deleted
Deleted Member
Member since January 1970
Posts: 0
|
MOHS
Jul 2, 2013 12:49:25 GMT -5
Post by Deleted on Jul 2, 2013 12:49:25 GMT -5
Don't get depressed. There are things that can be done. For example, there are many antiviral compounds that are quite effective against cancers as well such as betulinic acid. And cancer cells can be selectively killed by several means. For example, skin cancers can be selectively treated with the application of food grade (35%) peroxide. The process is painful though as concentrated peroxide burns like you are being branded. Only hurts for about 20 minutes though. And if it is basal cell, there is a topical cream chemotherapy that targets it specifically. www.cancer.org/cancer/skincancer-basalandsquamouscell/detailedguide/skin-cancer-basal-and-squamous-cell-treating-other-local-therapiesAll the best Sheltie!
|
|
|
MOHS
Jul 2, 2013 15:51:02 GMT -5
Post by vegasjames on Jul 2, 2013 15:51:02 GMT -5
You are full of tantalizing factoids, James!!! Peroxide kills skin cancer?! Wouldn't that be topical only? How would that get to the subcutaneous portions of the tumor?? Can you actually get ahead of tumor growth by continuously killing the visible part of it (with the peroxide), wouldn't it eventually grow inward so the peroxide would eventually become ineffective? And I actually wondered about this... why wouldn't lasers work on skin cancer, the under skin types? They have multiple different lasers for melting fat under skin layers now, if it can melt fat, couldn't they be directed at melting tumors from within? Great subject! Yes, peroxide kills cancer cells. In fact, this is how our own natural killer (NK) cells kill cancer cells when they can be detected by the immune system. Unfortunately, cancer cells have developed various means to evade the immune system, which is why the immune system rarely destroys cancer cells in the body including actual tumors. Therefore, the primary role of the immune system in cancer is not the direct control of cancer cells but rather tumor causing pathogens. When the immune system is capable of detecting malignant cells though the NK cells attach to the malignant cell and inject peroxide in to the cell to destroy the cell. The reason this works and why peroxide selectively destroys cancer cells is because healthy cells contain various enzymes such as catalase and superoxide dismutase that break down the peroxides to protect the cells. Cancer cells on the other hand do not contain these enzymes. When they are exposed to peroxides the peroxides enter the cancer cells causing them to swell and burst. When using 35% peroxide, which is concentrated, the use is strictly topical. And it is is not recommended around very sensitive tissue such as the eyes since the peroxide will burn tissue. With healthy tissue though healthy skin cells only get mildly burnt like a very mild sunburn. They are not destroyed like cancer cells. Some people will dilute the peroxide to a 3% solution then do therapy by dropping one drop in a glass of water then drinking it on an empty stomach. Then they work up to two drops, then three........ The process is very slow though and would not be quick enough in most cases to deal with cancers. Ozone therapy, which also works in large part of the peroxide principle is much faster and safer. The reaction is a chain reaction and so will follow the tumor inward. In short, as the peroxide breaks down there is a highly reactive singlet oxygen formed, which reacts with the lipid membranes of the cancer cells to form a lipid peroxide. As the lipid peroxide is broken down another highly reactive singlet oxygen is formed starting the whole process over. To give you an example, I once saw .01ml of 35% peroxide take out half of a tumor the size of golf ball in seconds. Eventually all the singlet oxygens get used up by reacting with other singlet oxygens forming O2 or by reacting with other substances. Another friend of mine had a tumor a little larger than a quarter. When the peroxide was applied to the opened tumor the peroxide immediately destroyed all the malignant cells leaving a crater about 1//4 inch under her skin as the peroxide followed the cancer cells downward. Cancer cells can be "cooked" to destroy them. This technology has been around since the 1950s, but is not widely used for the simple fact it is cheap and effective just like many other cancer cures that have existed for decades or for even more than a century. Cancer is an extremely big and profitable business making massive amounts of revenue for both big business, non profit groups such as the American Cancer Society, and for the government. This is why you always hear about these really promising developments they claim will take 14 years to develop to bring it to market yet they never make it to the market. Anyway, hyperthermia utilizes radio-frequency to heat up the tumor literally cooking it to death. Malignant tumors cannot dissipate heat as easily as healthy tissue so the heat can build up sufficiently in the tumor to kill it. Lasers could be used to destroy tumors, but this would be more likely by coagulation of the blood vessels feeding the tumor. Same principle as coagulating spider veins to get rid of them. Unfortunately this would not cure the cancer. The out cells could survive by getting oxygen from diffusion in the same manner cells from newly developing tumors do. It would be harder to develop a laser that could selectively cook malignant cells without cooking healthy tissue.
|
|
|
MOHS
Jul 2, 2013 15:59:25 GMT -5
Post by vegasjames on Jul 2, 2013 15:59:25 GMT -5
Another point that should be brought up is that sunlight increases vitamin D levels, which is actually anti-cancer. So there is a lot of hype over sunlight causing skin cancer. You are right about the melanomas. Consider how often people develop them on their backs even though they always wear shirts out in the sun. Again, the sun does not cause the cancer, the virus causes the cancer and there can be various triggers that activate cancer viruses such as sunlight, hormones, carcinogens, immune suppression, other viruses, etc. Thanks James! (or do you go by Jim?) This topic is dear to me for the personal connection I mentioned earlier. There was a study in Australia regarding skin cancer and sunscreen. Perhaps not coincidentally, sunscreen was invented in Australia. The incidence of skin cancer's of all kinds increased beginning the year after sunscreen was introduced to the public. It continued to increase until it found a new plateau. Further, that study referred (or vise versa) to another Aussie study in which they surveyed skin cancer patients in many various job descriptions. The highest rate of skin cancer was among office workers of all kinds. Lifeguarding is a real career there so there are great numbers of folks who spend 200++ days a year for 20++ years in the sun, and the study showed they have the lowest rate of skin cancer. Definitely James. I hate being called Jim. My grandfather was Jim, my father is Jim, I have always gone by my given name James. There has been a lot of controversy over the whole sun causing cancer and sunscreen protecting from cancer subject. The pro-sunscreen and anti-sun advocates keep over looking the facts that sunscreens are full of known carcinogens and sunlight produces anti-cancer vitamin D. Thanks for posting the additional information.
|
|